effects pedals and loss of tone
If you use pedals you will lose some high end of your guitar tone. Main reason is the cable length! You need a cable from guitar to effect, between effects and from effects back to your amp. Long cables suck tone! This it noticeable with cables longer than 18 ft (5,5 meters).
Pedals with a buffer circuit where the solution. The buffer will keep your signal in shape. So there is no tone loss with long cables.
Down side to some buffers are that they do affect your tone.
So the next step is true bypass pedals. True by pass will take away the signal from the circuit when the pedal is off. That is a good thing, but there is still a problem. You will lose high end because of cable length!
That is the reason why it is still a good idea to use a buffer in your effect chain. Personally I use a Boss TU-2 tuner placed first in my chain. Like all Boss pedals it has a buffered circuit, so after the tuner my signal is consistent. That works for me.